Salidroside (SAL) is a high-altitude-extracted phenylpropanoid glycoside monomer from Rhodiola. It has been demonstrated to be neuroprotective in illnesses of the Central Nervous System (CNS) and to have protective effects against myocardial infarction, liver cancer, renal fibrosis, and other organ diseases. In particular, SAL can alleviate neurological dysfunction and a number of pathogenic reactions in CNS illnesses. The pharmacological effects of SAL on inflammation, oxidative stress, apoptosis, autophagy, and neural regeneration were clarified by this review. Additionally, it is evaluated how SAL influences different signaling pathways to control pathogenic processes in CNS disorders. Uncertainty persists regarding the connections between distinct routes and the processes at various phases of the disease process.
