In order to achieve accurate tumors margin detection, nano-particles are being used for more detailed nuclear imaging. The resolution of nuclear imaging systems is very limited and therefore, magnification is needed. For magnified imaging, a single pinhole collimator (typically a double cone shape), between the object and the gamma detector, can collect magnified projections. The sensitivity in gamma imaging systems such as SPECT using a pinhole collimator, is inversely proportional to the square of the object to pinhole distance. However, the projection size on the gamma detector (which is relative to the size of the object) is determined by the ratio of the distance between detector to pinhole and the distance between pinhole to object. The sensitivity of the pinhole SPECT system must increase severely for using nano-particles in nuclear imaging. Thus, a multiple pinhole SPECT is used. A novel configuration utilizes improved sensitivity efficiency with no resolution reduction for nano-particles objects imaging. The gamma imaging system is based on time multiplexing super resolution method using variable and dynamic pinhole arrays.
